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Ultra-pure; stabilizes microtubules
BML-T104-0005 5 mg 73.00 USD
BML-T104-0025 25 mg 249.00 USD
BML-T104-0250 250 mg 1,089.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-351-001

Antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polymerization. Reversibly binds to polymerized tubulin. Inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.

Product Details

Source:Isolated from the bark of the Pacific Yew tree (Taxus brevifolia).
MI:14: 6982
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO or methanol at 10mg/ml.
Long Term Storage:-20°C
Use/Stability:Store solutions at -20°C for up to 6 months.
Handling:Keep cool and dry.
Regulatory Status:RUO - Research Use Only
BML-T104 structure
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BML-T104 structure

Product Literature References

Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours: M. Ligia Sousa, et al.; Toxicon 175, 49 (2020), Abstract;
Know your ABCs: Characterization and gene expression dynamics of ABC transporters in the polyphagous herbivore Helicoverpa armigera: A. Bretschneider, et al.; Insect. Biochem. Mol. Biol. 72, 1 (2016), Application(s): Cell culture, Abstract;
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text

General Literature References

Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivo: P. Wagnet et al.; Cell Cycle 4, 1149 (2005), Abstract;
Paclitaxel for AIDS-associated Kaposi's sarcoma: T. Dhillon et al.; Expert. Rev. Anticancer Ther. 5, 215 (2005), Abstract;
Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer: D. Simpson & G.L. Plosker; Drugs 64, 1839 (2004), Abstract;
Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action: M. Abal et al.; Curr. Cancer Drug Targets 300, 193 (2003),
Overcoming multidrug resistance in taxane chemotherapy: R. Geney et al.; Clin. Chem. Lab. Med. 40, 918 (2002), Abstract;
Paclitaxel and its formulations: A.K. Singla et al.; Int. J. Pharm. 235, 179 (2002), Abstract;
Paclitaxel in cancer therapy: T.M. Mekhail & M. Markman; Expert Opin. Pharmacother. 3, 755 (2002), Abstract;
Taxol reactions: K.S. Price & M.C. Castells; Allergy Asthma Proc. 23, 205 (2002), Abstract;
The chemistry of taxol and related taxoids: D.G. Kingston et al.; Fortschr. Chem. Org. Naturst. 84, 53 (2002), Abstract;
Chemistry and chemical biology of taxane anticancer agents: M.L. Miller & I. Ojima; Chem. Rec. 1, 195 (2001), Abstract;
Disruption of cell adhesion and caspase-mediated proteolysis of beta- and gamma-catenins and APC protein in paclitaxel-induced apoptosis: Y. Ling et al.; Mol. Pharmacol. 59, 593 (2001), Abstract;
Taxol: biosynthesis, molecular genetics, and biotechnological applications: S. Jennewein & R. Croteau; Appl. Microbiol. Biotechnol. 57, 13 (2001), Abstract;
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together: T.H. Wang et al.; Cancer 88, 2619 (2000), Abstract;
Molecular effects of paclitaxel: myths and reality (a critical review): M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999), Abstract;
CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells: Y.D. Yoo et al.; Clin. Cancer. Res. 4, 3063 (1998), Abstract;
Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells: R. Danesi, et al.; Mol. Pharmacol. 47, 1106 (1995), Abstract;
Inhibition of neurite initiation and growth by taxol: P.C. Letourneau & A.H. Ressler; J. Cell Biol. 98, 1355 (1984), Abstract;

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