Replaces Prod. #: ALX-351-001
Antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polymerization. Reversibly binds to polymerized tubulin. Inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.
Product Details
| Formula: | C47H51NO14 |
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| MW: | 853.9 |
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| Source: | Isolated from the bark of the Pacific Yew tree (Taxus brevifolia). |
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| CAS: | 33069-62-4 |
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| MI: | 14: 6982 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO or methanol at 10mg/ml. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store solutions at -20°C for up to 6 months. |
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| Handling: | Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Cell culture,
Abstract;
Full Text
General Literature References
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