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Dihydrosphingosine, D-erythro

Sphingosine precursor
BML-SL125-0010 10 mg 82.00 USD
BML-SL125-0050 50 mg 347.00 USD
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Replaces Prod. #: ALX-306-008

Biosynthetic precursor of sphingosine. Inhibitor of protein kinase C (PKC). Blocks phospholipases A2 (PLA2) and the D-sphingosine precursor.

Product Details

Alternative Name:D-erythro-Sphingosine, Dihydro-, Sphinganine
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in 100% ethanol (25mg/ml, warm) or DMSO (25mg/ml, warm).
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases: T. Narita, et al.; Sci. Rep. 6, 25469 (2016), Application(s): Cell culture, Abstract; Full Text
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60): B.Y. Yung, et al.; BBRC 199, 888 (1994), Abstract;
Glucocorticoid stimulation of amnion cell prostaglandin synthesis: suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C: T. Zakar, et al.; Biochim. Biophys. Acta 1136, 161 (1992), Abstract;
Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine: R.C. Franson, et al.; Biochim. Biophys. Acta 1136, 169 (1992), Abstract;
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds: A.H. Merrill, Jr., et al.; Biochemistry 28, 3138 (1989), Abstract;
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s): A.H. Merrill & E. Wang; J. Biol. Chem. 261, 3764 (1986), Abstract;
In vivo studies on the introduction of the 4-t-double bond of the sphingenine moiety of rat brain ceramides: D.E. Ong & R.N. Brady; J. Biol. Chem. 248, 3884 (1973), Abstract;

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