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α2-Macroglobulin (human plasma), (purified)

Protease inhibitor
BML-SE502-0001 1 mg 115.00 USD
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Product Details

MW:725 kDa
Source:Isolated from human plasma that is tested to be negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.
UniProt ID:P01023
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:In addition to binding TGF-β and β-amyloid, α2-macroglobulin covalently binds and inhibits a wide range of proteases, including ADAMs, calpains, cathepsins, chymase, clotting factors, kallikreins, MMPs, neutrophil elastase, and proteinase 3.  It also plays a role in the innate immune system, inhibiting parasitic proteases.  When treated with methylamine, it blocks binding of apoE to lipoprotein receptor-related protein (LRP).
Regulatory Status:RUO - Research Use Only

Product Literature References

Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation: L. Wang, et al.; Toxicology 357, 33 (2016), Abstract;

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