Product Details
| MW: | 725 kDa |
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| Source: | Isolated from human plasma that is tested to be negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2. |
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| UniProt ID: | P01023 |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | In addition to binding TGF-β and β-amyloid, α2-macroglobulin covalently binds and inhibits a wide range of proteases, including ADAMs, calpains, cathepsins, chymase, clotting factors, kallikreins, MMPs, neutrophil elastase, and proteinase 3. It also plays a role in the innate immune system, inhibiting parasitic proteases. When treated with methylamine, it blocks binding of apoE to lipoprotein receptor-related protein (LRP). |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation: L. Wang, et al.; Toxicology
357, 33 (2016),
Abstract;
