Product Details
| Alternative Name: | Protein kinase Cα |
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| MW: | 103 kDa |
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| Source: | Produced in insect cells. Full length active PKCa (protein kinase C α) is fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system. |
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| UniProt ID: | P17252 |
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| Application Notes: | Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | PKCα is a member of the PKC family of serine- and threonine-specific protein kinases that can be activated by calcium and diacylglycerol. It has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy: E. Schmid, et al.; Nat. Med.
21, 1298 (2015),
Application(s): In vitro phosphorylation of RKIP by PKC,
Abstract;
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