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14-3-3θ/τ (human), (recombinant) (His-tag)

BML-SE487-0100 100 µg 384.00 USD
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Product Details

MW:~30 kDa
Source:Produced in E. coli. Human 14-3-3τ/θ is fused at the C-terminus to a His-tag.
UniProt ID:P27348
Formulation:Liquid. In 50mM NaH2PO4, pH 8.0, 300mM NaCl.
Purity:≥90% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Application Notes:Drug screening, protein-protein interaction studies, gel overlays.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Scientific Background:14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. 14-3-3θ/t has been shown to be present in testis and 14-3-3θ mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. Both PKCµ and Bax have been shown to be negatively regulated by 14-3-3θ
Regulatory Status:RUO - Research Use Only

General Literature References

C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3: T. Schwarz, et al.; BBRC 394, 890 (2010), Abstract;
14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax.: M. Nomura et al.; J Biol Chem 278, 2058 (2003), Abstract;
How do 14-3-3 proteins work? Gatekeeper phosphorylation and the molecular anvil hypothesis.: M.B. Yaffe; FEBS Lett. 513, 53 (2002), Abstract;
A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.: A. Malaspina et al.; J. Neurochem. 75, 2511 (2000), Abstract;
Characterization of a novel transcript of 14-3-3 theta in Sertoli cells.: J. Chaudhary & M.K. Skinner; J. Androl. 21, 730 (2000), Abstract;
Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins.: A. Hausser et al.; J. Biol. Chem. 274, 9258 (1999), Abstract;
14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.: R.W. Furlanetto et al.; Biochem. J. 327, 765 (1997), Abstract;
Molecular cloning and tissue-specific expression of the mouse homologue of the rat brain 14-3-3 theta protein: characterization of its cellular and developmental pattern of expression in the male germ line.: L. Perego & G. Berruti; Mol. Reprod. Dev. 47, 370 (1997), Abstract;

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