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Cathepsin L (human liver), (purified)

BML-SE201-0025 25 µg 509.00 USD
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Replaces Prod. #: ALX-200-314

Product Details

Source:Isolated from human liver. Negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.
UniProt ID:P07711 (cathepsin L1)
Purity:≥95% by SDS-PAGE
Application Notes:Useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:Cathepsin L is a lysosomal protease that can also be secreted from the cell and is involved in protein degradation, arthritis, and cancer.
Regulatory Status:RUO - Research Use Only

Product Literature References

Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations: V. Bonatto, et al.; J. Chem. Inf. Model 61, 4733 (2021), Abstract;
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;

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