Replaces Prod. #: ALX-200-314
Product Details
| Source: | Isolated from human liver. Negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2. |
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| UniProt ID: | P07711 (cathepsin L1) |
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| Purity: | ≥95% by SDS-PAGE |
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| Application Notes: | Useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Cathepsin L is a lysosomal protease that can also be secreted from the cell and is involved in protein degradation, arthritis, and cancer. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations: V. Bonatto, et al.; J. Chem. Inf. Model
61, 4733 (2021),
Abstract;
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem.
85, 505 (2019),
Application(s): Activity assay,
Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.)
50, 10875 (2014),
Abstract;
