An endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. Potent inhibitor of endothelial cell proliferation and migration. Inhibits bFGF and VEGF-induced corneal neovascularization in mice. Posttranscriptionally downregulates HIF-1α expression.
Product Details
| Alternative Name: | 2-ME |
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| Formula: | C19H26O3 |
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| MW: | 302.4 |
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| CAS: | 362-07-2 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White solid. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway: Y.C. Hsieh, et al.; Dev. Comp. Immunol.
53, 85 (2015),
Application(s): Injection into shrimp,
Abstract;
Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy: S. Lorin, et al.; Autophagy
6, 153 (2010),
Abstract;
