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Proteasome 20S β1 subunit monoclonal antibody (MCP421)

BML-PW8140-0025 25 µl 151.00 USD
BML-PW8140-0100 100 µl 466.00 USD
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Product Details

Alternative Name:Proteasome subunit β type-6, Macropain δ chain, Proteasome subunit Y
Immunogen:Dinitrophenylated proteasomes.
UniProt ID:P28072
Gene/Protein Identifier:PSMB6 (gene name)
Source:Purified from mouse ascites.
Species reactivity:Human
Rabbit, Yeast
Specificity:Recognizes the β1 subunit of the 20S proteasome.
Applications:IHC, WB
Purity Detail:Protein G-affinity purified ascites.
Formulation:Liquid. In PBS containing 10mM sodium azide.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Blue Ice
Long Term Storage:-20°C
Technical Info/Product Notes:Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from "standard" nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins.
Regulatory Status:RUO - Research Use Only
Proteasome 20S β1 subunit monoclonal antibody (MCP421) Western blot
Western blot analysis of Proteasome 20S β1 subunit, mAb (MCP421) (Prod. No. BML-PW8140): Lane 1: MW marker, Lane 2: HeLa (Prod. No. ADI-LYC-HL100), Lane 3: HeLa S100 fraction (Prod. No. BML-SW8750), Lane 4: 3T3 (Prod. No. ADI-LYC-3T100).
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Proteasome 20S β1 subunit monoclonal antibody (MCP421) Western blot

Product Literature References

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator: M.A. Vasilopoulou, et al.; Redox Biol. 56, 10262 (2022), Abstract;
Red Blood Cell Proteasome in Beta-Thalassemia Trait: Topology of Activity and Networking in Blood Bank Conditions: A.T. Anastasiadi, et al.; Membranes 11, 716 (2021), Abstract;
An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice: T. Homma & J. Fujii; Biochim. Biophys. Acta Gen. Subj. 1863, 1108 (2019), Application(s): Mouse cryosectioned tissue, Abstract;
Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma: D. Brunnert, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1865, 1666 (2019), Abstract;
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival: S. Benvegnu, et al.; Mol. Cell 66, 358 (2017), Abstract;
Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism: P.A. Erokhov, et al.; Oncotarget 8, 70695 (2017), Abstract; Full Text
Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts: A. Desvergne, et al.; Free Radic. Biol. Med. 94, 195 (2016), Application(s): Western blot, Abstract;
Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux: L.M. Bollinger, et al.; Obesity (Silver Spring) 23, 1185 (2015), Application(s): Western Blot, Abstract; Full Text
SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes: T. Homma, et al.; Arch. Biochem. Biophys. 583, 65 (2015), Application(s): Immunoblotting, Abstract;
The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells: Y.N. Rui, et al.; Autophagy 11, 812 (2015), Abstract; Full Text
Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity: A. Belogurov Jr, et al.; FASEB J. 29, 1901 (2015), Abstract; Full Text
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract; Full Text
Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS: V. Dechavanne, et al.; Protein Exp. Purif. 87, 100 (2013), Application(s): Western blot, Abstract;
Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy: P. Balsas, et al.; Leuk. Res. 36, 212 (2012), Application(s): Western blot, Abstract;
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions: Z. Lukic, et al.; Retrovirology 8, 93 (2011), Abstract; Full Text

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