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SUMO-1 (human) polyclonal antibody

BML-PW0505A-0025 25 µg 138.00 USD
BML-PW0505A-0100 100 µg 458.00 USD
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Replaces Prod. #: BML-PW0505

Product Details

Alternative Name:Sentrin-1, Small ubiquitin-related modifier 1
Immunogen:Full length recombinant human SUMO-1.
UniProt ID:P63165
Source:Purified from rabbit serum.
Species reactivity:Human
Crossreactivity:Species cross-reactivity expected to be high due to conservation of SUMO sequence.
Applications:ICC, IP, WB
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Store diluted antibody at +4°C, do not freeze and use within 1 month.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:SUMO (small ubiquitin-related modifier) is a member of a family of ubiquitin-like proteins involved in the regulation of the cellular functions of a wide variety of proteins. Four members of the SUMO family have been described in vertebrates, SUMO-1 and the close homologues SUMO-2 and SUMO-3, with some 50% homology between SUMO-1 and SUMO-2/3. Although a fourth SUMO (SUMO-4) has been reported, there remains considerable debate as to whether this is a real and expressed gene product.
Regulatory Status:RUO - Research Use Only
SUMO-1 (human) polyclonal antibody Immunocytochemistry
Figure 1: Hela cells were fixed with paraformaldehyde and stained with SUMO-1 antibody (BML-PW0505A) at 1:100 dilution.
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SUMO-1 (human) polyclonal antibody Immunocytochemistry

Product Literature References

Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein: L. Cilenti, et al.; Sci. Rep. 10, 1609 (2020), Abstract; Full Text
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1: J. Brown, et al.; J. Virol. 90, 5939 (2016), Application(s): Immunofluorescence, Abstract; Full Text

General Literature References

A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus: K.M. Bohren, et al.; J. Biol. Chem. 279, 27233 (2004), Abstract;
SUMO, ubiquitin’s mysterious cousin: S. Muller, et al.; Nat. Rev. Mol. Cell Biol. 2, 202 (2001), Abstract;

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