Replaces Prod. #: ALX-430-045
Synthetic type II pyrethroid. Potent calcineurin (protein phosphatase 2B) inhibitor IC50~0.03 nM. Causes an increase in neurotransmitter release at synapses and also increases intrasynaptosomal Ca2+ levels. May also have varied effects on ion channels.
Product Details
| Alternative Name: | (S)-α-Cyano-(3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate |
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| Formula: | C22H19Br2NO3 |
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| MW: | 505.2 |
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| CAS: | 52918-63-5 |
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| MI: | 14: 2883 |
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| Purity: | ≥98% (External Standard Method) |
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| Appearance: | Beige solid. |
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| Solubility: | Soluble in DMSO (40mg/ml) or ethanol (15mg/ml, warm); insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Class II pyrethroids: noninhibitors calcineurin: A. Enz & E. Pombo-Villar; Biochem. Pharmacol.
54, 321 (1997),
Abstract;
Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids: E. Enan & F. Matsumura; Biochem. Pharmacol.
45, 703 (1993),
Abstract;
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; Trends Pharmacol. Sci.
13, 236 (1992),
Abstract;
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol.
43, 1777 (1992),
Abstract;
