A novel substrate-based (γ-40 site) aldehyde inhibitor of γ-secretase. In whole cells overexpressing amloid ß protein precursor, Boc-GVV-CHO dose-dependently inhibited amyloid ß cleavage. γ-secretase is an important therapeutic target for strategies designed to lower amyloid ß production.
Product Details
| Alternative Name: | Boc-GVV-CHO |
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| Sequence: | Boc-GVV-CHO |
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| Formula: | C17H31N3O5 |
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| MW: | 357.5 |
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| Source: | Synthetic. |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (>25 mg/ml) or ethanol (10 mg/ml warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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