Replaces Prod. #: ALX-307-079
Activates Ca2+-insensitive PKC isotypes δ, ε and η. Binds to GRP1 via a PH domain.
Product Details
| Alternative Name: | PtdIns(3,4,5)P3, (1,2-dipalmitoyl)-, 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate . 7Na |
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| Formula: | C41H75O22P4 . 7Na |
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| MW: | 1204.8 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥98% (TLC) |
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| Solubility: | Soluble in water (10mg/ml) or in chloroform/methanol/water (1:1:0.3) (>10mg/ml). |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains: J.K.Klarlund, et al.; Science
275, 1927 (1997),
Abstract;
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3: A. Toker, et al.; J. Biol. Chem.
269, 32358 (1994),
Abstract;
