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United States 

12-Deoxyphorbol 13-acetate

PKC activator
BML-PE187-0001 1 mg 156.00 USD
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Replaces Prod. #: ALX-445-009

A non-tumor promoting phorbol ester, which acts as a PKC partial agonist. Protects T-lymphoblastoid cells from the killing effects of HIV-1. Upregulates latent HIV-1 provirus expression and inhibits HIV infection and viral spread at the entry/fusion step of viral life cycle. Does not induce tumor formation.

Product Details

Alternative Name:Prostratin
Purity:≥99% (HPLC, TLC)
Appearance:White to off white crystalline powder.
Solubility:Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells: T.L. Sung & A.P. Rice; Retrovirology 3, 66 (2006), Abstract;
Prostratin as a new therapeutic agent targeting HIV viral reservoirs: M. Hezareh; Drug News Perspect. 18, 496 (2005), Abstract;
Prostratin antagonizes HIV latency by activating NF-kappaB: S.A. Williams, et al.; J. Biol. Chem. 279, 42008 (2004), Abstract;
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin: Z. Szallasi, et al.; Cancer Res. 53, 2507 (1993), Abstract;
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1: K.R. Gustafson, et al.; J. Med. Chem. 35, 1978 (1992), Abstract;
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex: S. Zayed, et al.; Experientia 33, 1554 (1977), Abstract;
The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata: A.R. Cashmore & R.N. Seelye; Tetrahedron Lett. 17, 1737 (1976),