Replaces Prod. #: ALX-445-009
A non-tumor promoting phorbol ester, which acts as a PKC partial agonist. Protects T-lymphoblastoid cells from the killing effects of HIV-1. Upregulates latent HIV-1 provirus expression and inhibits HIV infection and viral spread at the entry/fusion step of viral life cycle. Does not induce tumor formation.
Product Details
| Alternative Name: | Prostratin |
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| Formula: | C22H30O6 |
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| MW: | 390.5 |
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| CAS: | 60857-08-1 |
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| Purity: | ≥99% (HPLC, TLC) |
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| Appearance: | White to off white crystalline powder. |
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| Solubility: | Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells: T.L. Sung & A.P. Rice; Retrovirology
3, 66 (2006),
Abstract;
Prostratin as a new therapeutic agent targeting HIV viral reservoirs: M. Hezareh; Drug News Perspect.
18, 496 (2005),
Abstract;
Prostratin antagonizes HIV latency by activating NF-kappaB: S.A. Williams, et al.; J. Biol. Chem.
279, 42008 (2004),
Abstract;
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin: Z. Szallasi, et al.; Cancer Res.
53, 2507 (1993),
Abstract;
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1: K.R. Gustafson, et al.; J. Med. Chem.
35, 1978 (1992),
Abstract;
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex: S. Zayed, et al.; Experientia
33, 1554 (1977),
Abstract;
The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata: A.R. Cashmore & R.N. Seelye; Tetrahedron Lett. 17, 1737 (1976),
