Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Phorbol 12,13-dibutyrate

PKC activator
BML-PE135-0005 5 mg 269.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-445-001

Widely used PKC activator (10-100ng/ml). Less potent than phorbol 12-.myristate 13-acettate (PMA; TPA) (Prod. No. BML-PE160), but also less hydrophobic.

Product Details

Purity:≥99% (HPLC)
Appearance:Colorless oil.
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Multiple transduction pathways mediate thyrotropin receptor signaling in preosteoblast-like cells: A. Boutin, et al.; Endocrinology 157, 2173 (2016), Application(s): Cell culture, Abstract; Full Text
Phorbol esters: structure, biological activity, and toxicity in animals: G. Goel, et al.; Int. J. Toxicol. 26, 279 (2007), Abstract;
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva et al.; Eur. J. Pharmacol. 491, 101 (2004), Abstract;
Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line: M.S. Johnson et al.; Mol. Cell. Biochem. 165, 65 (1996), Abstract;
Okadaic acid stimulates ouabain-sensitive 86Rb(+)-uptake and phosphorylation of the Na+/K(+)-ATPase alpha-subunit in rat hepatocytes: C.J. Lynch et al.; FEBS Lett. 355, 157 (1994), Abstract;
Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation: C. Lisbona et al.; Eur. J. Immunol. 24, 2746 (1994), Abstract;
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells: J.P. Middleton et al.; J. Biol. Chem. 268, 15958 (1993), Abstract;
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells: T.L. Yue et al.; Neurochem. Res. 17, 997 (1992), Abstract;
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension: G.E. Bilder et al.; J. Pharmacol. Exp. Ther. 252, 526 (1990), Abstract;
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets: D.E. MacIntyre et al.; FEBS Lett. 180, 160 (1985), Abstract;
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters: M. Castagna et al.; J. Biol. Chem. 257, 7847 (1982), Abstract;

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
PKC Activator
By catalog section:


Technical Service
Customer Service