Replaces Prod. #: ALX-445-001
Widely used PKC activator (10-100ng/ml). Less potent than phorbol 12-.myristate 13-acettate (PMA; TPA) (Prod. No. BML-PE160), but also less hydrophobic.
Product Details
| Formula: | C28H40O8 |
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| MW: | 504.6 |
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| CAS: | 37558-16-0 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Colorless oil. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Multiple transduction pathways mediate thyrotropin receptor signaling in preosteoblast-like cells: A. Boutin, et al.; Endocrinology
157, 2173 (2016),
Application(s): Cell culture,
Abstract;
Full Text
Phorbol esters: structure, biological activity, and toxicity in animals: G. Goel, et al.; Int. J. Toxicol.
26, 279 (2007),
Abstract;
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva et al.; Eur. J. Pharmacol.
491, 101 (2004),
Abstract;
Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line: M.S. Johnson et al.; Mol. Cell. Biochem.
165, 65 (1996),
Abstract;
Okadaic acid stimulates ouabain-sensitive 86Rb(+)-uptake and phosphorylation of the Na+/K(+)-ATPase alpha-subunit in rat hepatocytes: C.J. Lynch et al.; FEBS Lett.
355, 157 (1994),
Abstract;
Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation: C. Lisbona et al.; Eur. J. Immunol.
24, 2746 (1994),
Abstract;
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells: J.P. Middleton et al.; J. Biol. Chem.
268, 15958 (1993),
Abstract;
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells: T.L. Yue et al.; Neurochem. Res.
17, 997 (1992),
Abstract;
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension: G.E. Bilder et al.; J. Pharmacol. Exp. Ther.
252, 526 (1990),
Abstract;
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets: D.E. MacIntyre et al.; FEBS Lett.
180, 160 (1985),
Abstract;
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters: M. Castagna et al.; J. Biol. Chem.
257, 7847 (1982),
Abstract;
