Product Details
| Alternative Name: | Autocamtide-2-related inhibitory peptide (myristoylated) |
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| Sequence: | N-Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu |
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| MW: | 1708.1 |
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| Source: | Synthetic. |
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| Formulation: | Lyophilized. Trifluoroacetate salt. |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | Powder. |
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| Solubility: | Soluble in 30% Acetic Acid in Water (5 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from moisture. |
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| Technical Info/Product Notes: | AIP (autocamtide-2-related inhibitory peptide, Prod. No. BML-P211) is a highly-specific and potent inhibitor of CaM kinase II. The sequence is derived from autocamtide-2 (Prod. No. BML-P101) but alanine is substituted for threonine at the 9-position. AIP at 1 µM completely inhibited CaM kinase II but did not affect PKC, PKA, CaMKIV and other brain extract kinases. Myristoylated AIP (Prod. No. BML-P212) is the same sequence as AIP but is N-terminal myristoylated to increase cell-permeability. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase A: R.K. Devulapalli, et al.; Neuroscience
418, 1 (2019),
Abstract;
The role of CaMKII in neuropathic pain and fear memory in chronic constriction injury in rats: Y. Qian, et al.; Int. J. Neurosci.
129, 146 (2019),
Abstract;
CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval: T.J. Jarome, et al.; Neurobiol. Learn. Mem.
128, 103 (2016),
Application(s): Cell culture,
Abstract;
