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AIP (myristoylated)

CaM kinase inhibitor
BML-P212-0500 0.5 mg 131.00 USD
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Product Details

Alternative Name:Autocamtide-2-related inhibitory peptide (myristoylated)
Formulation:Lyophilized. Trifluoroacetate salt.
Purity:≥95% (HPLC)
Identity:Determined by MS.
Solubility:Soluble in 30% Acetic Acid in Water (5 mg/ml).
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Handling:Protect from moisture.
Technical Info/Product Notes:AIP (autocamtide-2-related inhibitory peptide, Prod. No. BML-P211) is a highly-specific and potent inhibitor of CaM kinase II. The sequence is derived from autocamtide-2 (Prod. No. BML-P101) but alanine is substituted for threonine at the 9-position.  AIP at 1 µM completely inhibited CaM kinase II but did not affect PKC, PKA, CaMKIV and other brain extract kinases. Myristoylated AIP (Prod. No. BML-P212) is the same sequence as AIP but is N-terminal myristoylated to increase cell-permeability.
Regulatory Status:RUO - Research Use Only

Product Literature References

Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase A: R.K. Devulapalli, et al.; Neuroscience 418, 1 (2019), Abstract;
The role of CaMKII in neuropathic pain and fear memory in chronic constriction injury in rats: Y. Qian, et al.; Int. J. Neurosci. 129, 146 (2019), Abstract;
CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval: T.J. Jarome, et al.; Neurobiol. Learn. Mem. 128, 103 (2016), Application(s): Cell culture, Abstract;

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