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Z-VVR-AMC

Substrate for cathepsin S and cathepsin L
 
BML-P199-0010 10 mg 130.00 USD
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Sensitive fluorogenic substrate for cathepsin S and cathepsin L. Also cleaved by cathepsin B, cathepsin V, kallikrein 8, and factor VIIa/TF but not cathepsin K nor kallikrein 2. Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Product Specification

Alternative Name:Cathepsin S & L substrate (fluorogenic)
 
Sequence:Z-Val-Val-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
 
MW:663.8
 
CAS:124485-41-2
 
Purity:≥99% (TLC)
 
Appearance:Lyophilized solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress: H. Kristen, et al.; Neurobiol. Aging 68, 5 (2018), Abstract;
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L.(Coleoptera: Curculionidae): S. Ben-Mahmoud, et al.; J. Insect Physiol. 72, 1 (2015), Abstract;
Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells: P. Xu, et al.; J. Ocul. Pharmacol. Ther. 30, 246 (2014), Abstract; Full Text
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge: K. Porter, et al.; PLoS One 8, e68668 (2013), Abstract; Full Text

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