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ACE substrate
BML-P161-0001 1 mg 155.00 USD
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Fluorogenic substrate for angiotensin converting enzyme-1 (ACE1). The somatic form of ACE1 is a zinc-dependent peptidyl dipeptidase comprising two catalytic domains referred to as the N- and C-domains. The testicular form, due to a downstream start site, contains only the C-domain. Abz fluorescence is quenched by the Dnp group until cleavage (at Arg-Lys) separates them. Ex: 320 nm, Em: 420 nm. This quenched substrate is useful for assay of plasma, tissue, and cell culture ACE1 activity, inhibitor screening and kinetic analysis.

Product Details

Alternative Name:ACE1 substrate (fluorogenic)
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease: R. MacLachlan, et al.; Aging Brain 3, 100062 (2023), Abstract;
Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models: M.J. Everett, et al.; ACS Infect. Dis. 9, 270 (2023), Abstract;
Activation of angiotensin-converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling: R. Dang, et al.; Aging Cell 20, 13480 (2021), Abstract;
Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae: M. Everett, et al.; Antimicrob. Agents Chemother. 62, e00074 (2018), Abstract; Full Text
Chymase-dependent production of angiotensin II: an old enzyme in old hearts: G. Froogh, et al.; Am. J. Physiol. Heart Circ. Physiol. 312, H223 (2017), Abstract;

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By target:
Angiotensin converting enzyme
By biological activity:
Angiotensin converting enzyme Substrate
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