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OMNIMMP® fluorogenic substrate

Highly quenched and sensitive fluorogenic MMP substrate
BML-P126-0001 1 mg 266.00 USD
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Replaces Prod. #: ALX-260-125

Fluorogenic substrate for nearly all matrix metalloproteinase (MMP) enzymes, and ADAM17/TACE. This highly-quenched (99.5%) substrate is useful for inhibitor screening and kinetic analysis. Ex.: 328 nm, Em.: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control Peptide (BML-P127).

Product Details

Alternative Name:Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 . AcOH, Matrix metalloproteinase substrate
Sequence:Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 . AcOH
[Mca=(7-methoxycoumarin-4-yl)acetyl; Dpa=N-3-(2,4-dinitrophenyl)-L-a,β-diaminopropionyl]
Solubility:Soluble in methanol (1mg/ml) or DMSO (20mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling: K. van Kuijk, et al.; Cardiovasc. Res. 118, 1232 (2022), Abstract;
Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds: H. Seo, et al.; Inorg. Chem. 61, 7631 (2022), Abstract;
Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2: W. Bassiouni, et al.; Can. J. Physiol. Pharmacol. 100, 184 (2022), Abstract;
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells: R. Solga, et al.; Eur. J. Cell Biol. 98, 151046 (2019), Abstract;
Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth: M. Tauro, et al.; Mol. Cancer Ther. 16, 494 (2017), Abstract; Full Text
Intracoronary delivery of recombinant TIMP-3 after myocardial infarction: effects on myocardial remodeling and function: S.C. Barlow, et al.; Am. J. Physiol. Heart Circ. Physiol. 313, H690 (2017), Abstract; Full Text
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment: G. Shay, et al.; Oncotarget 8, 41827 (2017), Abstract; Full Text
Synthesis and binding monitoring of a new nanomolar PAMAM-based matrix metalloproteinases inhibitor (MMPIs): L. Cerofolini, et al.; Bioorg. Med. Chem. 25, 523 (2017), Abstract;
C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes: N. J. Peake, et al.; Biochem. Biophys. Res. Commun. 465, 784 (2015), Application(s): Total MMP activity in human chondrocytes, Abstract;
CRM197 in combination with shRNA interference of VCAM-1 displays enhanced inhibitory effects on human glioblastoma cells: Y. Hu, et al.; J. Cell. Physiol. 230, 1713 (2015), Abstract;
Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency: S.C. Cardinale, et al. ; Botulinum. J. 2, 16 (2015), Application(s): Performed MMP Fret assays, Abstract; Full Text
Interleukin-13 deficiency aggravates healing and remodeling in male mice after experimental myocardial infarction: U. Hofmann, et al.; Circ. Heart Fail. 7, 822 (2014), Abstract;
Artemether combined with shRNA interference of vascular cell adhesion molecule-1 significantly inhibited the malignant biological behavior of human glioma cells: Y.B. Wang, et al.; PLoS One 8, e60834 (2013), Abstract; Full Text
Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts: D.T. Ploeger, et al.; Cell Commun. Signal. 11, 29 (2013), Abstract; Full Text
Hydrogen peroxide-induced necrotic cell death in cardiomyocytes is independent of matrix metalloproteinase-2: M.A. Ali, et al.; Toxicol. In Vitro 27, 1686 (2013), Application(s): Total MMP activity in rat cardiomyocytes, Abstract;
Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2: M.M. Castro, et al.; Biochem. Pharmacol. 86, 469 (2013), Abstract;
Investigating the selectivity of metalloenzyme inhibitors: J.A. Day, et al.; J. Med. Chem. 56, 7997 (2013), Abstract; Full Text
The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice: L.A. McConnachie, et al.; PLoS One 8, e64165 (2013), Application(s): Total MMP activity in lung homogenates, Abstract; Full Text
A highly soluble matrix metalloproteinase-9 inhibitor for potential treatment of dry eye syndrome: M. Mori, et al.; Basic Clin. Pharmacol. Toxicol. 111, 289 (2012), Abstract;
Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeutics: T.J. Edkins, et al.; J. Pharm. Biomed. Anal. 70, 408 (2012), Application(s): Endogenous MMP Activity in Human serum, Abstract;
Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate: B.S. Mayer, et al.; J. Biol. Chem. 287, 37857 (2012), Abstract; Full Text
Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2: V.J. Cadele, et al.; FEBS J. 279, 2444 (2012), Abstract; Full Text
Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice: C.S. Weldy, et al.; Inhal. Toxicol. 23, 724 (2011), Application(s): Total MMP activity in lung homogenates, Abstract; Full Text
In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane: L. Bédouet, et al.; Toxicol. In Vitro 25, 1944 (2011), Application(s): Total MMP activity in explant media, Abstract;
Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction: Z. Sahul, et al.; Circ. Cardiovasc. Imaging 4, 381 (2011), Application(s): Assay, WB of pig cardiac tissue, Abstract; Full Text
Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury: S.E. Gill, et al.; Am. J. Pathol. 176, 64 (2010), Application(s): Total MMP activity in bronchoalveolar lavage and lung homogenates, Abstract; Full Text
Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice: J.A. Zavadzkas, et al.; Am. J. Physiol. Heart Circ. Physiol. 295, H1394 (2008), Application(s): Total MMP activity in left ventricular myocardial extracts, Abstract; Full Text
Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E: J. Asbun, et al.; Am. J. Physiol. Circ. Physiol. 288, H227 (2005), Application(s): Total MMP activity in culture supernatants and cell lysates, Abstract; Full Text

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