A-803467 is a potent and selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8 which is preferentially expressed on sensory neurons. IC50 for human Nav1.8=8.0 nM (140 nM for rat). It attenuates neuropathic and inflammatory pain in various animal models.
Product Details
| Formula: | C19H16ClNO4 |
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| MW: | 357.8 |
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| Source: | Synthetic. |
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| CAS: | 944261-79-4 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (15mg/ml) or 100% ethanol (2mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats: S. McGaraughty, et al.; J. Pharmacol. Exp. Ther.
324, 1204 (2008),
Abstract;
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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat: M.F. Jarvis, et al.; Proc. Natl. Acad. Sci. USA
104, 8520 (2007),
Abstract;
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