Replaces Prod. #: ALX-550-060
Selective κ-opioid agonist. Thought to be selective for the κ-1 subtype (KD=3.8nM in human cerebral cortex membranes). Immunomodulatory activity.
Product Details
| Formula: | C22H32N2O2 |
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| MW: | 356.5 |
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| Source: | Synthetic. |
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| CAS: | 96744-75-1 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 100% ethanol, 0.1N hydrogen chloride, or DMSO. Insoluble in water or 0.1N sodium hydroxide. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ligand binding profiles of U-69, 593-sensitive and-insensitive sites in human cerebral cortex membranes: evidence of kappa opioid receptors heterogeneity: K.W. Kim et al.; Life Sci.
58, 1671 (1996),
Abstract;
Immunomodulatory activity of mu- and kappa-selective opioid agonists: D.D. Taub et al.; PNAS
88, 360 (1991),
Abstract;
Kappa-opioid receptors and analgesia: M.J. Millan; Trends Pharmacol. Sci.
11, 70 (1990),
Abstract;
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes: R.B. Rothman et al.; Eur. J. Pharmacol.
167, 345 (1989),
Abstract;
