Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

5-Ketoeicosa-6E,8Z,11Z,14E-tetraenoic acid

R527 ligand
 
BML-K005-0050 50 µg 211.00 USD
Do you need bulk/larger quantities?
 
Stimulates neutrophil degranulation and Ca2+ mobilization by a mechanism independent of the LTB4 receptor. Has been shown to act as an agonist at a G protein-coupled receptor (R527). Induces the infiltration of granulocytes into human skin.

Product Details

Formula:C20H30O3
 
MW:318.5
 
CAS:106154-18-1
 
Concentration:50 µg/ml
 
Formulation:Oil dissolved in ethanol
 
Purity:≥95% (HPLC)
 
Appearance:Liquid.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Store, as supplied, at -80°C for up to 1 year.
 
Regulatory Status:RUO - Research Use Only
 
bml-k005
Please mouse over
bml-k005

Product Literature References

5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin: S. Muro, et al.; J. Allergy Clin. Immunol. 112, 768 (2003), Abstract;
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils: C.E. Jones, et al.; Mol. Pharmacol. 63, 471 (2003), Abstract; Full Text
5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration: W.S. Powell, et al.; J. Immunol. 154, 4123 (1995), Abstract;
5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements: U. Schwenk & J.M. Schroeder ; J. Biol. Chem. 270, 15029 (1995), Abstract;
Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils: W.S. Powell, et al.; J. Lipid Res. 36, 2590 (1995), Abstract; Full Text
5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus: J.T. O'Flaherty, et al.; Biochem. Biophys. Res. Commun. 192, 129 (1993), Abstract;

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

All new literature pieces