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15(S)-Hydroperoxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid (HPETE)

Prostacyclin synthase inhibitor
BML-HP015-0050 50 µg 97.00 USD
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Replaces Prod. #: ALX-340-058

Primary metabolite of arachidonic acid via the 15-lipoxygenase pathway. Inhibits prostacyclin synthase and arachidonic acid induced platelet aggregation. Endogenous TRPV1 agonist.

Product Details

Alternative Name:15(S)-HPETE
Concentration:50µg/ml for 50µg size and 1mg/ml for 1mg size.
Formulation:Oil dissolved in ethanol
Purity:≥98% (HPLC)
Solubility:Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml).
Shipping:Dry Ice
Long Term Storage:-80°C
Use/Stability:Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes. For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. For HPLC, aliquots of ethanol solutions should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration.
Handling:After opening, prepare aliquots and store at -80°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances: S.W. Hwang, et al.; PNAS 97, 6155 (2000), Abstract;
Inhibition of platelet aggregation, malonyldialdehyde and thromboxane formation by hydroperoxides of arachidonic acid: D. Aharony, et al.; Thromb. Haemostasis 46, 265 (1981),
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation: S. Moncada, et al.; Prostaglandins 12, 715 (1976), Abstract;

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