Replaces Prod. #: ALX-340-058
Primary metabolite of arachidonic acid via the 15-lipoxygenase pathway. Inhibits prostacyclin synthase and arachidonic acid induced platelet aggregation. Endogenous TRPV1 agonist.
Product Details
| Alternative Name: | 15(S)-HPETE |
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| Formula: | C20H32O4 |
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| MW: | 336.5 |
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| CAS: | 70981-96-3 |
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| Concentration: | 50µg/ml for 50µg size and 1mg/ml for 1mg size. |
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| Formulation: | Oil dissolved in ethanol |
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| Purity: | ≥98% (HPLC) |
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| Solubility: | Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml). |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes. For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. For HPLC, aliquots of ethanol solutions should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration. |
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| Handling: | After opening, prepare aliquots and store at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances: S.W. Hwang, et al.; PNAS
97, 6155 (2000),
Abstract;
Inhibition of platelet aggregation, malonyldialdehyde and thromboxane formation by hydroperoxides of arachidonic acid: D. Aharony, et al.; Thromb. Haemostasis 46, 265 (1981),
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation: S. Moncada, et al.; Prostaglandins
12, 715 (1976),
Abstract;
