Biosynthesis in human neutrophils, eosinophils and reticulocytes. Most abundant eicosanoid in human bronchi. Regulates T lymphocyte mitogenesis. Induces immunosupression. Stimulates migration of capillary endothelial cells and neovascularization.
Product Details
| Alternative Name: | 15(S)-HETE |
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| MW: | 320.5 |
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| Source: | Synthetic. |
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| CAS: | 54845-95-3 |
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| Formulation: | Oil dissolved in ethanol. |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Liquid. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Profiling oxylipins released from human platelets activated through the GPVI collagen receptor: R.E. Turnbull, et al.; Prostaglandins Other Lipid Mediat.
158, 106607 (2022),
Abstract;
Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol.
16, 851 (2019),
Abstract;
15-Hydroxyeicosatetraenoic acid stimulates migration of human retinal microvessel endothelium in vitro and neovascularization in vivo: J. E. Graeber, et al.; Prostaglandins
39, 665 (1990),
Abstract;
Adrenal synthesis of corticosterone in response to ACTH in rats is influenced by leukotriene A4 and by lipoxygenase intermediates: D. B. Jones, et al.; J. Endocrinol.
112, 253 (1987),
Abstract;
The inhibitory role of 12- and 15-lipoxygenase products on renin release: I. Antonipillai, et al.; Hypertension
10, 61 (1987),
Abstract;
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Immunosuppression induced in vivo by 15 hydroxyeicosatetraenoic acid (15 HETE): J. C. Aldiger, et al.; Prostaglandins Leukot. Med.
13, 99 (1984),
Abstract;
15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase: J. Y. Vanderhoek, et al.; J. Biol. Chem.
255, 5996 (1980),
Abstract;
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Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid: J. Y. Vanderhoek, et al.; J. Biol. Chem.
255, 10064 (1980),
Abstract;
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