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15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid (HETE)

BML-H015-0050 50 µg 100.00 USD
BML-H015-1000 1 mg 1,185.00 USD
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Biosynthesis in human neutrophils, eosinophils and reticulocytes. Most abundant eicosanoid in human bronchi. Regulates T lymphocyte mitogenesis. Induces immunosupression. Stimulates migration of capillary endothelial cells and neovascularization.

Product Details

Alternative Name:15(S)-HETE
Formulation:Oil dissolved in ethanol.
Purity:≥99% (HPLC)
Shipping:Dry Ice
Long Term Storage:-80°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Profiling oxylipins released from human platelets activated through the GPVI collagen receptor: R.E. Turnbull, et al.; Prostaglandins Other Lipid Mediat. 158, 106607 (2022), Abstract;
Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol. 16, 851 (2019), Abstract;
15-Hydroxyeicosatetraenoic acid stimulates migration of human retinal microvessel endothelium in vitro and neovascularization in vivo: J. E. Graeber, et al.; Prostaglandins 39, 665 (1990), Abstract;
Adrenal synthesis of corticosterone in response to ACTH in rats is influenced by leukotriene A4 and by lipoxygenase intermediates: D. B. Jones, et al.; J. Endocrinol. 112, 253 (1987), Abstract;
The inhibitory role of 12- and 15-lipoxygenase products on renin release: I. Antonipillai, et al.; Hypertension 10, 61 (1987), Abstract; Full Text
Immunosuppression induced in vivo by 15 hydroxyeicosatetraenoic acid (15 HETE): J. C. Aldiger, et al.; Prostaglandins Leukot. Med. 13, 99 (1984), Abstract;
15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase: J. Y. Vanderhoek, et al.; J. Biol. Chem. 255, 5996 (1980), Abstract; Full Text
Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid: J. Y. Vanderhoek, et al.; J. Biol. Chem. 255, 10064 (1980), Abstract; Full Text

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