Replaces Prod. #: ALX-340-037
Biosynthesis in human neutrophils, phorbol ester-treated mouse epidermis and by hepatic microsomal cytochrome P-450. Chemotactic for neutrophils. Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Details
| Alternative Name: | 8(S)-HETE |
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| Formula: | C20H32O3 |
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| MW: | 320.5 |
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| CAS: | 98462-03-4 |
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| Concentration: | 50μg/ml |
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| Formulation: | Liquid. In ethanol. |
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| Purity: | ≥99% (HPLC) |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -80°C. |
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| Technical Info/Product Notes: | Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. For HPLC, aliquots of ethanol solutions should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans: Y. Guan, et al.; Am. J. Physiol.
273, F1013 (1997),
Abstract;
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu, et al.; J. Biol. Chem.
270, 23975 (1995),
Abstract;
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites: H.H. Lo, et al.; Lipids
29, 547 (1994),
Abstract;
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin: M.A, Hughes & A.R. Brash; Biochim. Biophys. Acta
1081, 347 (1991),
Abstract;
