Novel Sirt activator structurally based on a dihydropyridine scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) =1μM for Sirt1 with weaker effect on Sirt2 and Sirt3 (25 and 50μM respectively). The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells.
Product Details
| Alternative Name: | N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine |
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| Formula: | C24H25NO4 |
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| MW: | 391.5 |
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| Source: | Synthetic. |
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| CAS: | 15301-69-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (5mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors: A. Mai, et al.; J. Med. Chem.
52, 5496 (2009),
Abstract;
