Replaces Prod. #: ALX-270-310
Novel cell-permeable p53 reactivating agent. Restores sequence-specific DNA binding and the active conformation to mutant p53 (in 13 of 14 p53 mutants tested) in vitro and in living cells. Induces apoptosis in human tumor cell lines and displays antitumor activity in mice.
Product Details
| Alternative Name: | 2,2-bis(Hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one, 2,2-bis(Hydroxymethyl)-3-quinuclidinone |
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| Formula: | C9H15NO3 |
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| MW: | 185.2 |
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| CAS: | 5608-24-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble at 25 mg/ml in ethanol, 100% DMSO, and DMF. Soluble at 10 mg/ml in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store stock solutions at-20°C for up to 3 months. Storage of aqueous solutions is not recommended. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound: V.J. Bykov, et al.; Nat. Med.
8, 282 (2002),
Abstract;
