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Chelator that can induce differentiation in tumor cells
BML-FR110-0250 250 mg 267.00 USD
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Hinokitiol (β-thujaplicin) is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells and tyrosinase, most likely via metal chelation.

Product Details

Purity:≥98% (GC)
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

(-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production: D. S. Kim, et al.; Arch. Pharm. Res. 27, 334 (2004), Abstract;
Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase: H. Suzuki, et al.; Biochem. Biophys. Res. Commun. 275, 885 (2000), Abstract;
Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constituents of Thujopsis dolabrata S. and Z. hondai MAK: Y. Inamori, et al.; Biol. Pharm. Bull. 22, 990 (1999), Abstract;
Apoptosis during iron chelator-induced differentiation in F9 embryonal carcinoma cells: T. Tanaka, et al.; Cell Biol. Int. 23, 541 (1999), Abstract;
Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3: Y. Ido, et al.; Cell Prolif. 32, 63 (1999), Abstract;
Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes: T. Baba, et al.; J. Invest. Dermatol. 110, 24 (1998), Abstract; Full Text

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