Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


Antioxidant. SIRT1 activator.
BML-FR104-0100 100 mg 62.00 USD
BML-FR104-0500 500 mg 270.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-270-125

Phenolic antioxidant found in grapes and wine. Potent activator of human deacetylase SIRT1 (maximum effect at 100-200μM). Increases longevity in yeast. Displays antiproliferative effect on human breast epithelial cells. Displays a variety of pharmacological activities including: estrogen receptor agonist activity, inhibition of ribonucleotide reductase and DNA synthesis, inhibition of eicosanoid synthesis, cell cycle arrest at S/G2 phase and induction of apoptosis. Inhibits PKD in vitro (IC50=200μM) and in vivo (IC50=800μM), but not PKC isoforms. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis. Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. 

Product Details

Alternative Name:trans-3,4',5-Trihydroxystilbene
MI:14: 8158
Purity:≥98% (HPLC)
Appearance:White to yellow solid.
Solubility:Soluble in DMSO (65mg/ml), 100% ethanol or dimethyl formamide; slightly soluble in water (0.1mg/ml).
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Sirtuins transduce STACs signals through steroid hormone receptors: H.K. Bayele, et al.; Sci. Rep. 10, 5338 (2020), Abstract; Full Text
Effects of resveratrol supplementation in male Wistar rats undergoing an endurance exercise and acute exercise training: R. Vafaee, et al.; Hum. Antibodies 27, 257 (2019), Application(s): Treatment of rats, Abstract;
Resveratrol induces mitochondrial apoptosis and inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma cells: S.E. Kim, et al.; Nutr. Cancer. 70, 125 (2018), Abstract;
Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function: Z. Meng, et al.; Am. J. Transl. Res. 8, 2641 (2016), Application(s): RSV replacement for overiectomized mice, assessing estrogen replacement affects on cardiac function, Abstract; Full Text
Effects of Resveratrol and Vitamin C on the Self-Renewal Capacity of Blast Progenitors in Hematologic Malignancies: Y. Zhang, et al.; J. Leuk. S1, 006 (2015), Application(s): Cell Culture, Full Text
Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-kappaB activation and peroxisome proliferator-activated receptor-gamma upregulation: C. Rius, et al.; J. Immunol. 185, 3718 (2010), Abstract;
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008), Abstract;
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006), Abstract;
Mechanism of Human SIRT1 Activation by Resveratrol: MT. Borra, et al.; J. Biol. Chem. 280, 17187 (2005), Abstract;
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004), Abstract;
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004), Abstract;
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003), Abstract;
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002), Abstract;
Inhibition of protein kinase D by resveratrol: R.S. Haworth & M. Avkiran; Biochem. Pharmacol. 62, 1647 (2001), Abstract;
Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells: J. Dörrie, et al.; Cancer Res. 61, 4731 (2001), Abstract; Full Text
Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation: J.R. Stewart, et al.; Biochem. Pharmacol. 60, 1355 (2000), Abstract;
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999), Abstract;
Antiproliferative effect of synthetic resveratrol on human breast epithelial cells: O.P. Mgbonyebi, et al.; Int. J. Oncol. 12, 865 (1998), Abstract;
Resveratrol arrests the cell division cycle at S/G2 phase transition: F.D. Ragione, et al.; BBRC 250, 53 (1998), Abstract;
Resveratrol, a remarkable inhibitor of ribonucleotide reductase: M. Fontecave, et al.; FEBS Lett. 421, 277 (1998), Abstract;
Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells: S. Chanvitayapongs, et al.; Neuroreport 8, 1499 (1997), Abstract;
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997), Abstract;
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor: B.D. Gehm, et al.; PNAS 94, 14138 (1997), Abstract; Full Text
Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996), Abstract;
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease: C.R. Pace-Asciak, et al.; Clin. Chem. Acta 235, 207 (1995), Abstract;

Related Products


CYP1A1 inhibitor
537-42-8, Synthetic., ≥98% (HPLC) | Print as PDF
ALX-385-034-M025 25 mg 86.00 USD
ALX-385-034-M100 100 mg 173.00 USD
Do you need bulk/larger quantities?

Related Literature

Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Stem Cells
Stem Cells
Download as PDF

Download as PDF

All new literature pieces

Recommend this page

Keep in touch

©2021 Enzo Life Sciences, Inc.,