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Antioxidant. SIRT1 activator.
BML-FR104-0100 100 mg 73.00 USD
BML-FR104-0500 500 mg 321.00 USD
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Replaces Prod. #: ALX-270-125

Phenolic antioxidant found in grapes and wine. Potent activator of human deacetylase SIRT1 (maximum effect at 100-200μM). Increases longevity in yeast. Displays antiproliferative effect on human breast epithelial cells. Displays a variety of pharmacological activities including: estrogen receptor agonist activity, inhibition of ribonucleotide reductase and DNA synthesis, inhibition of eicosanoid synthesis, cell cycle arrest at S/G2 phase and induction of apoptosis. Inhibits PKD in vitro (IC50=200μM) and in vivo (IC50=800μM), but not PKC isoforms. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis. Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. 

Product Details

Alternative Name:trans-3,4',5-Trihydroxystilbene
MI:14: 8158
Purity:≥98% (HPLC)
Appearance:White to yellow solid.
Solubility:Soluble in DMSO (65mg/ml), 100% ethanol or dimethyl formamide; slightly soluble in water (0.1mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rat: L.N. Tamini, et al.; Eur. Rev. Med. Pharmacol. Sci. 2, 325 (2023), Abstract;
Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells: L. Liu, et al.; Stem Cell Rev. Rep. 18, 1478 (2022), Abstract;
Sirtuins transduce STACs signals through steroid hormone receptors: H.K. Bayele, et al.; Sci. Rep. 10, 5338 (2020), Abstract; Full Text
Effects of resveratrol supplementation in male Wistar rats undergoing an endurance exercise and acute exercise training: R. Vafaee, et al.; Hum. Antibodies 27, 257 (2019), Application(s): Treatment of rats, Abstract;
Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats: D.K. Yang & H.S. Kang; Biomol. Ther. (Seoul) 26, 130 (2018), Application(s): Intraperitoneal injection into rats, Abstract; Full Text
Resveratrol induces mitochondrial apoptosis and inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma cells: S.E. Kim, et al.; Nutr. Cancer. 70, 125 (2018), Abstract;
Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function: Z. Meng, et al.; Am. J. Transl. Res. 8, 2641 (2016), Application(s): RSV replacement for overiectomized mice, assessing estrogen replacement affects on cardiac function, Abstract; Full Text
Effects of Resveratrol and Vitamin C on the Self-Renewal Capacity of Blast Progenitors in Hematologic Malignancies: Y. Zhang, et al.; J. Leuk. S1, 006 (2015), Application(s): Cell Culture, Full Text
Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-kappaB activation and peroxisome proliferator-activated receptor-gamma upregulation: C. Rius, et al.; J. Immunol. 185, 3718 (2010), Abstract;
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008), Abstract;
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006), Abstract;
Mechanism of Human SIRT1 Activation by Resveratrol: MT. Borra, et al.; J. Biol. Chem. 280, 17187 (2005), Abstract;
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004), Abstract;
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004), Abstract;
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003), Abstract;
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002), Abstract;
Inhibition of protein kinase D by resveratrol: R.S. Haworth & M. Avkiran; Biochem. Pharmacol. 62, 1647 (2001), Abstract;
Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells: J. Dörrie, et al.; Cancer Res. 61, 4731 (2001), Abstract; Full Text
Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation: J.R. Stewart, et al.; Biochem. Pharmacol. 60, 1355 (2000), Abstract;
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999), Abstract;
Antiproliferative effect of synthetic resveratrol on human breast epithelial cells: O.P. Mgbonyebi, et al.; Int. J. Oncol. 12, 865 (1998), Abstract;
Resveratrol arrests the cell division cycle at S/G2 phase transition: F.D. Ragione, et al.; BBRC 250, 53 (1998), Abstract;
Resveratrol, a remarkable inhibitor of ribonucleotide reductase: M. Fontecave, et al.; FEBS Lett. 421, 277 (1998), Abstract;
Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells: S. Chanvitayapongs, et al.; Neuroreport 8, 1499 (1997), Abstract;
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997), Abstract;
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor: B.D. Gehm, et al.; PNAS 94, 14138 (1997), Abstract; Full Text
Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996), Abstract;
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease: C.R. Pace-Asciak, et al.; Clin. Chem. Acta 235, 207 (1995), Abstract;

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