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Fibronectin (cellular) (human) monoclonal antibody (DH1)

BML-FG6010-0100 100 µl 270.00 USD
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Product Details

Alternative Name:cFn
Immunogen:Purified fibronectin from A8387 fibrosarcoma cells.
UniProt ID:P02751
Species reactivity:Human
Specificity:Recognizes the extra domain A (ED) of cellular fibronectin (cFn). Recognizes cFN in malignant tumors, does not cross-react with benign tumors or normal tissues.
Applications:ICC, WB
Application Notes:Detects a band of ~ 250kDa by Western blot.
Purity Detail:Protein A affinity chromatography.
Formulation:Liquid. In PBS containing 0.1% sodium azide and 1mg/mL BSA.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Fibronectins are high molecular weight, disulphide-linked, dimeric cell adhesion glycoproteins found in basement membranes and in the interstitial connective tissue matrix. A single fibronectin gene is subject to alternative splicing in a cell-type-, development- and age-regulated manner which gives rise to multiple molecular forms. In addition to their prominent role in adhesion, fibronectins have been reported to mediate various aspects of cellular interaction, including migration during development and wound-healing, haemostasis, and the regulation of cell growth and differentiation. Cellular fibronectins (cFn) are found in low amounts in normal human plasma and tissues, but they are abundant in the plasma of carcinoma patients and in the stroma of various carcinomas. In contrast, a soluble form of fibronectin produced by hepatocytes is readily detectable in plasma and becomes deposited in pericellular matrices and within tissues. This form of fibronectin, referred to as ‘plasma fibronectin’ (pFn), differs from cFn by the absence of an amino acid sequence, known as extra domain A1.
Regulatory Status:RUO - Research Use Only

Product Literature References

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1: J. Jin, et al.; Respir. Res. 20, 119 (2019), Abstract; Full Text

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