Replaces Prod. #: ALX-340-052
Endogenous cannabinoid agonist isolated from porcine brain. Binds specifically to CB1 (Ki=21.2nM) and CB2 (Ki=>3µM) receptors. Causes sedation hypothermia, intestinal immobility and mild antinociception in mice. Chemically stable, but less potent than 2-arachidonoylglycerol (Prod. No. BML-FA028) with an endogenous half-life time of hours rather than minutes.
Product Details
| Alternative Name: | 2-Arachidonyl glyceryl ether, 2-AG ether, 5Z,8Z,11Z,14Z-Eicosatetraen-2-glyceryl ether |
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| Formula: | C23H40O3 |
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| MW: | 364.6 |
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| CAS: | 222723-55-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow oil. |
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| Solubility: | Soluble in DMSO (40mg/ml) or ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C when stored under an atmosphere of argon or nitrogen. |
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| Handling: | Protect from oxygen. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors: J.L. Shoemaker, et al.; J. Pharmacol. Exp. Ther.
315, 828 (2005),
Abstract;
Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice: Y. Avraham, et al.; Brain Res. Bull.
65, 117 (2005),
Abstract;
Further advances in the synthesis of endocannabinoid-related ligands: A. Mahadevan and R.K. Razdan; AAPS J.
7, E496 (2005),
Abstract;
Full Text
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors: J.L. Shoemaker, et al.; J. Pharmacol. Exp. Ther.
314, 868 (2005),
Abstract;
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion: K. Nithipatikom, et al.; Cancer Res.
64, 8826 (2004),
Abstract;
Full Text
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor: M. Duncan, et al.; Br. J. Pharmacol.
142, 509 (2004),
Abstract;
Full Text
Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors: G. Appendino, et al.; Bioorg. Med. Chem. Lett.
13, 43 (2003),
Abstract;
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid: K. Laine, et al.; Invest. Ophthalmol. Vis. Sci.
43, 3216 (2002),
Abstract;
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues: F. Fezza, et al.; FEBS Lett.
513, 294 (2002),
Abstract;
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor: L. Hanus, et al.; PNAS
98, 3662 (2001),
Abstract;
