Replaces Prod. #: ALX-340-053
Non-pungent, potent and highly selective agonist of the cannabinoid CB1 receptor (Ki=1.4nM). Displays >1’400-fold selectivity over CB2 receptors (Ki=3.1µM). Active in vivo.
Product Details
| Alternative Name: | ACEA, N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide |
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| Formula: | C22H36NOCl |
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| MW: | 366.0 |
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| CAS: | 220556-69-4 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale yellow oil. |
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| Solubility: | Soluble in DMSO (25mg/ml) or ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C when stored under an inert atmosphere. |
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| Handling: | Protect from air. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide: T.J. Price, et al.; Br. J. Pharmacol.
141, 1118 (2004),
Abstract;
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints: C.L. Baker and J.J. McDougall; Br. J. Pharmacol.
142, 1361 (2004),
Abstract;
Full Text
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors: A. Franklin, et al.; Eur. J. Pharmacol.
474, 195 (2003),
Abstract;
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1): C.J. Hillard, et al.; J. Pharmacol. Exp. Ther.
289, 1427 (1999),
Abstract;
