Chemical inducer of autophagy which acts via an mTOR-independent mechanism. It increased autophagosome synthesis and enhanced the clearance of model autophagy substrates such as A53T α-synuclein and mutant huntingtin fragments. It reduced Aβ peptide and AAP-CTF levels in an Alzheimers model and attenuated mutant huntingtin-fragment toxicity in Huntington’s disease models, suggesting therapeutic potential.
Product Details
| Alternative Name: | 6-Bromo-4-allylaminoquinazoline |
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| Formula: | C11H10BrN3 |
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| MW: | 264.1 |
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| Source: | Synthetic. |
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| CAS: | 307538-42-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (8mg/ml) or 100% ethanol (2mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A small-molecule enhancer of autophagy decreases levels of Aß and APP-CTF via Atg5-dependent autophagy pathway: Y. Tian, et al.; FASEB J.
25, 1934 (2011),
Abstract;
Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys.
60, 173 (2011),
Abstract;
Full Text
Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases: M. Renna, et al.; J. Biol. Chem.
285, 11061 (2010),
Abstract;
Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models: S. Sarkar, et al.; Nat. Chem. Biol.
3, 331 (2007),
Abstract;
