DuP-697 is a highly selective and irreversible inhibitor of cyclooxygenase-2 (COX-2). (COX-2 IC50=10nM, COX-1 IC50=800nM). It is an orally effective anti-inflammatory, analgesic and antipyretic agent which is not ulcerogenic. Inhibition of COX-2 by DuP-697 and other inhibitors exacerbates ischemia-induced myocardial dysfunction in the rabbit. It inhibits angiogenesis and induces apoptosis in human endothelial cells.
Product Details
| Alternative Name: | (5-Bromo-2[4-fluorophenyl]-3-[4-methylsulfonyl-phenyl]thiophene) |
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| Formula: | C17H12BrFO2S2 |
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| MW: | 411.3 |
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| CAS: | 88149-94-4 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) or 100% ethanol (5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697): A. Churchman, et al.; Eur. J. Pharmacol.
573, 176 (2007),
Abstract;
Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit: G. Rossoni, et al.; Br. J. Pharmacol.
135, 1540 (2002),
Abstract;
Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase: R.A. Copeland, et al.; PNAS USA
91, 11202 (1994),
Abstract;
Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor: K.R. Gans, et al.; J. Pharmacol. Exp. Ther.
254, 180 (1990),
Abstract;
