Irreversible, non-toxic, cell-permeable inhibitor of cysteine proteases calpain, cathepsins B and L, and Trypanosome trypanopain. Can be used in vitro (typically 20 µM) or in vivo. Inhibits tumor formation and growth.
Product Details
Alternative Name: | N-Morpholineurea-phenylalanyl-homophenylalanylfluoromethyl ketone |
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Sequence: | Mu-Phe-hPhe-FMK |
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Formula: | C25H30FN3O4 |
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MW: | 455.5 |
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Purity: | ≥98% (TLC) |
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Appearance: | White solid. |
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Solubility: | Soluble in DMSO (>25 mg/ml). |
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Shipping: | Blue Ice |
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Long Term Storage: | +4°C |
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Use/Stability: | Store, as supplied, at 4°C for up to 1 year. Store DMSO concentrates at -20°C for up to 1 year. Do not store dilute solutions. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers: L. A. Couto, et al.; J. Neurosci. Res.
77, 410 (2004),
Abstract;
Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei: V. P. Triggs & J. D. Bangs; Eukaryot. Cell.
2, 76 (2003),
Abstract;
Full Text
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B: C. J. F. Van Noorden, et al.; Clin. Exp. Metastasis
16, 159 (1998),
Abstract;
Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo: M.M. Wasilewski, et al.; Mol. Biochem. Parasitol.
81, 179 (1996),
Abstract;
The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design: J.H. McKerrow, et al.; Parasitol. Today
11, 279 (1995),
Abstract;
Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis: R. E. Esser, et al.; Arthritis Rheum.
37, 236 (1994),
Abstract;
Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts: C. J. F. Van Noorden & V. Everts; Biochem. Biophys. Res. Commun.
178, 178 (1991),
Abstract;