Blebbistatin (so named because of its ability to block cell blebbing) is a selective and high-affinity (IC50 approx. 4 µM) inhibitor of non-muscle myosin II. During cell division blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis. It inhibits pancreatic adenocarcinoma cellular invasiveness and PDGF-stimulated fibroblast-collagen matrix contraction.
Product Details
| Formula: | C18H16N2O2 |
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| MW: | 292.3 |
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| CAS: | 674289-55-5 |
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| Purity: | ≥97% |
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| Identity: | Determined by NMR. |
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| Appearance: | Bright yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules.: M. Martin, et al.; Elife
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Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor: A.F. Straight, et al.; Science
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