Replaces Prod. #: ALX-270-336
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells.
Product Details
| Alternative Name: | N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide |
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| Formula: | C23H23N3O3 |
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| MW: | 389.4 |
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| CAS: | 208260-29-1 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (200mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 3 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. Keep under inert gas. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Paradoxical activation of Raf by a novel Raf inhibitor: C.A. Hall-Jackson, et al.; Chem. Biol.
6, 559 (1999),
Abstract;
