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United States 

ZM 336372

Raf inhibitor
BML-EI298-0005 5 mg 185.00 USD
BML-EI298-0025 25 mg 750.00 USD
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Replaces Prod. #: ALX-270-336

Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells.

Product Details

Alternative Name:N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
Purity:≥95% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (200mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 3 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light. Keep under inert gas.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Paradoxical activation of Raf by a novel Raf inhibitor: C.A. Hall-Jackson, et al.; Chem. Biol. 6, 559 (1999), Abstract;