Replaces Prod. #: ALX-430-023
KN-93 is a potent, selective and cell-permeable inhibitor of CaM kinase II (IC50=370 nM). Does not significantly inhibit PKA. Causes cell-cycle arrest in NIH 3T3 fibroblasts and HeLa cells. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Product Details
| Formula: | C26H29ClN2O4S |
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| MW: | 501 |
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| CAS: | 139298-40-1 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | white to off-white solid |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 2 years after receipt. Stock solutions are stale for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol.
321, C549 (2021),
Abstract;
O GlcNAcylation contributes to intermittent hypoxia associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways: X. Guo, et al.; Mol. Med. Rep.
14, 744 (2021),
Abstract;
Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway: R. Zhang, et al.; J. Cell Physiol.
232, 2145 (2017),
Abstract;
Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells: G. Rasmussen & C. Rasmussen ; Biochem. Cell Biol.
73, 201 (1995),
Abstract;
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R. M. Tombes; Cell Growth. Differ.
6, 1063 (1995),
Abstract;
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya et al.; Biochem. Biophys. Res. Commun. 195, 608 (1993),
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki et al.; Biochem. Biophys. Res. Commun.
191, 255 (1993),
Abstract;
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi et al.; Biochem. Biophys. Res. Commun.
181, 968 (1991),
Abstract;
