Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


CaM kinase inhibitor
BML-EI268-0001 1 mg 211.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-430-023

KN-93 is a potent, selective and cell-permeable inhibitor of CaM kinase II (IC50=370 nM). Does not significantly inhibit PKA. Causes cell-cycle arrest in NIH 3T3 fibroblasts and HeLa cells. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Product Details

Purity:≥95% (HPLC)
Appearance:white to off-white solid
Solubility:Soluble in DMSO (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 2 years after receipt. Stock solutions are stale for up to 3 months when stored at -20°C.
Handling:Protect from light. Hygroscopic.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol. 321, C549 (2021), Abstract;
O GlcNAcylation contributes to intermittent hypoxia associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways: X. Guo, et al.; Mol. Med. Rep. 14, 744 (2021), Abstract;
Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway: R. Zhang, et al.; J. Cell Physiol. 232, 2145 (2017), Abstract;
Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells: G. Rasmussen & C. Rasmussen ; Biochem. Cell Biol. 73, 201 (1995), Abstract;
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R. M. Tombes; Cell Growth. Differ. 6, 1063 (1995), Abstract;
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya et al.; Biochem. Biophys. Res. Commun. 195, 608 (1993),
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki et al.; Biochem. Biophys. Res. Commun. 191, 255 (1993), Abstract;
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi et al.; Biochem. Biophys. Res. Commun. 181, 968 (1991), Abstract;