Replaces Prod. #: ALX-270-031
AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
Product Details
Alternative Name: | 3-Hydroxy-4-nitrobenzylidenemalononitrile |
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Formula: | C10H5N3O3 |
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MW: | 215.2 |
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CAS: | 118409-62-4 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Yellow solid. |
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MeltingPoint: | 181-182°C |
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Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm). |
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Shipping: | Ambient |
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Long Term Storage: | Ambient |
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Handling: | Store tightly sealed in the dark. Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat: L. Dugo, et al.; Intensive Care Med.
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Abstract;
The Tyrosine Kinase Inhibitor Tyrphostin AG 126 Reduces the Development of Colitis in the Rat: S. Cuzzocrea, et al.; Lab. Invest.
80, 1439 (2000),
Abstract;
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The Tyrosine Kinase Inhibitor Tyrphostin AG126 Reduces the Development of Acute and Chronic Inflammation: S. Cuzzocrea, et al.; Am. J. Pathol.
157, 145 (2000),
Abstract;
Full Text
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Abstract;
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