Replaces Prod. #: ALX-270-183
Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.
Product Details
| Alternative Name: | RG-50872, Malonaben, SF 6847 |
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| Formula: | C18H22N2O |
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| MW: | 282.4 |
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| CAS: | 10537-47-0 |
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| RTECS: | OO3737000 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or ethanol (20mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens: D. Arbon, et al.; Antimicrob. Agents Chemother.
66, e0072722 (2022),
Abstract;
Chemosensitization of glioblastoma cells to bis-dichloroethyl-nitrosourea with tyrphostin AG17: B.C. Liang & E. Ullyatt; Clin. Cancer Res.
4, 773 (1998),
Abstract;
The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2: G.A. Palumbo, et al.; Cancer Res.
57, 2434 (1997),
Abstract;
Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria: A.M. Burger, et al.; Cancer Res.
55, 2794 (1995),
Abstract;
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci.
12, 171 (1991),
Abstract;
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol.
260, C721 (1991),
Abstract;
The interaction of highly active uncouplers with mitochondria: H. Terada; Biochim. Biophys. Acta
639, 225 (1981),
Abstract;
