Replaces Prod. #: ALX-270-017
Cell permeable potent and selective inhibitor of cAMP- and cGMP-dependent protein kinases (PKA, Ki=48nM, and PKG) and protein kinase Cµ (PKCµ). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibited. Also inhibits Ca2+/calmodulin-dependent protein kinase II, casein kinase I and myosin light chain kinase. Induces apoptosis. Concentration range for cultured cells 30-100μM: osteoblastic cells, renal proximal tubule cells and Xenopus oocytes.
Product Details
| Alternative Name: | N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl |
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| Formula: | C20H20BrN3O2S·2HCl |
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| MW: | 519.3 |
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| CAS: | 127243-85-0 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white solid. |
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| MeltingPoint: | 141-143°C |
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| Solubility: | Soluble in DMSO (25mg/ml), methanol and 50% ethanol/water (20mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 4 months in DMSO. |
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| Technical Info/Product Notes: | Replacement for ADI-HPK-105 |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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