Replaces Prod. #: ALX-550-249
Selective cyclooxygenase (COX) inhibitor (IC50=14.9 µM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency (ID50=8.9-14 and 7.2-8.2 µM respectively; data are for (S) isomer). Clinically useful NSAID. Inhibits the neutrophil-dependent edema response of rabbit skin to C5a/PGE2.
Product Details
| Alternative Name: | α-Methyl-4-(2-methylpropyl)benzeneacetic acid, (±)-2-(4-Isobutylphenyl)propionic acid |
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| Formula: | C13H18O2 |
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| MW: | 206.3 |
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| CAS: | 15687-27-1 |
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| MI: | 14: 4881 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem.
268, 6610 (1993),
Abstract;
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition: M. Rampart & T.J. Williams; Biochem. Pharmacol.
35, 581 (1986),
Abstract;
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction: R.F. Myers & M.I. Siegel; Biochem. Biophys. Res. Commun.
112, 586 (1983),
Abstract;
