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PKC inhibitor
BML-EI154-0200 200 mg 81.00 USD
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Replaces Prod. #: ALX-270-113

Flavonoid. Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.

Product Details

MI:14: 7326
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR and MS.
Appearance:Off-white to beige solid.
Solubility:Soluble in acetone, DMSO, 100% ethanol or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Product may air oxidize in solution. Make solutions fresh daily.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells: M. Hassan, et al.; BBRC 361, 208 (2007), Abstract;
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets: V. Stangl, et al.; J. Nutr. 135, 172 (2005), Abstract;
Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae: T. Kasahara & M. Kasahara; Biochem. J. 315 (Pt1), 177 (1996), Abstract;
Functional differentiation of the human red blood cell and kidney urea transporters: S. Martial, et al.; Am. J. Physiol. 271, F1264 (1996), Abstract;
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis: D.S. Koh, et al.; Neurosci. Lett. 165, 167 (1994), Abstract;
Cloning and functional expression of a urea transporter from human bone marrow cells: B. Olives, et al.; J. Biol. Chem. 269, 31649 (1994), Abstract;
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C: N. Prevarskaya, et al.; Mol. Cell. Neurosci. 5, 699 (1994), Abstract;
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture: G.T. Berry, et al.; Pediat. Res. 35, 141 (1994), Abstract;
Thyroid hormones in tissues from fetal and adult rats: G. Morreale de Escobar; Endocrinology 134, 2410 (1994), Abstract;
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells: X. Wang, et al.; Biochem. J. 290, 249 (1993), Abstract;
Cloning and characterization of the vasopressin-regulated urea transporter: G. You, et al.; Nature 365, 844 (1993), Abstract;
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes: J. Kitanaka, et al.; J. Neurochem. 60, 704 (1993), Abstract;
Effects on water diffusion of inhibitors affecting various transport processes in human red blood cells: G. Benga, et al.; Eur. J. Cell Biol. 59, 219 (1992), Abstract;
Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds: M. Gschwendt, et al.; BBRC 124, 63 (1984), Abstract;