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Myelin basic protein inhibitor
BML-EI153-0010 10 mg 110.00 USD
BML-EI153-0050 50 mg 442.00 USD
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Replaces Prod. #: ALX-270-084

Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.

Product Details

Alternative Name:1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
Formula:C15H17N2O2SCl . HCl
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR and MS.
Appearance:White solid.
Solubility:Soluble in DMSO (10mg/ml) and ethanol/water (1:1, 10mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways: Y. Pang & P. Thomas; J. Steroid Biochem. Mol. Biol. 165, 258 (2017), Application(s): Involvement of kinase signaling pathways in stimulation of NO production, Abstract;
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes: U. Smith, et al.; Biochem. Biophys. Res. Commun. 268, 315 (2000), Abstract;
Stimulation of protein phosphatase-1 activity by insulin in rat adipocytes. Evaluation of the role of mitogen-activated protein kinase pathway: N. Begum; J. Biol. Chem. 270, 709 (1995), Abstract;
Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes: G. Inoue, et al.; J. Biol. Chem. 268, 5272 (1993), Abstract;
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells: J.A. Reig, et al.; Neurochem. Res. 18, 317 (1993), Abstract;
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle: M. Seto, et al.; Eur. J. Pharmacol. 195, 267 (1991), Abstract;
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells: T. Nagatsu, et al.; Biochem. Biophys. Res. Commun. 143, 1045 (1987), Abstract;
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987), Abstract;
The modulatory role of myosin light chain phosphorylation in human platelet activation: M. Saitoh, et al. ; Biochem. Biophys. Res. Commun. 140, 280 (1986), Abstract;

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