Replaces Prod. #: ALX-270-084
Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.
Product Details
Alternative Name: | 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl |
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Formula: | C15H17N2O2SCl . HCl |
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MW: | 361.3 |
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CAS: | 105637-50-1 |
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Purity: | ≥98% (TLC) |
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Identity: | Determined by 1H-NMR and MS. |
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Appearance: | White solid. |
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Solubility: | Soluble in DMSO (10mg/ml) and ethanol/water (1:1, 10mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | +4°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C. |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways: Y. Pang & P. Thomas; J. Steroid Biochem. Mol. Biol.
165, 258 (2017),
Application(s): Involvement of kinase signaling pathways in stimulation of NO production,
Abstract;
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes: U. Smith, et al.; Biochem. Biophys. Res. Commun.
268, 315 (2000),
Abstract;
Stimulation of protein phosphatase-1 activity by insulin in rat adipocytes. Evaluation of the role of mitogen-activated protein kinase pathway: N. Begum; J. Biol. Chem.
270, 709 (1995),
Abstract;
Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes: G. Inoue, et al.; J. Biol. Chem.
268, 5272 (1993),
Abstract;
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells: J.A. Reig, et al.; Neurochem. Res.
18, 317 (1993),
Abstract;
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle: M. Seto, et al.; Eur. J. Pharmacol.
195, 267 (1991),
Abstract;
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells: T. Nagatsu, et al.; Biochem. Biophys. Res. Commun.
143, 1045 (1987),
Abstract;
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem.
262, 7796 (1987),
Abstract;
The modulatory role of myosin light chain phosphorylation in human platelet activation: M. Saitoh, et al. ; Biochem. Biophys. Res. Commun.
140, 280 (1986),
Abstract;