Irreversible inhibitor of γ-glutamyl transpeptidase (GGT) ID50 = 0.54 mM. Inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4. Displays antitumor and anti-metastatic activity. Blocks H. Pylori GGT-induced T-cell inhibition. Inhibits bioactivation/release of nitric oxide from GSNO.
Product Details
| Alternative Name: | U-42126, AT-125 |
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| Formula: | C5H7ClN2O3 |
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| MW: | 178.6 |
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| CAS: | 42228-92-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (max. 18mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione: P.C. Turnbull, et al.; Am. J. Physiol. Cell Physiol.
317, C1278 (2019),
Abstract;
Full Text
Functional characterisation of glutathione export from the rat lens: A. Umapathy, et al.; Exp. Eye Res.
166, 151 (2018),
Abstract;
A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death: T.L. Thorn, et al.; ASN Neuro.
7, 1177 (2015),
Application(s): Cell culture ,
Abstract;
Full Text
A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase: J.B. King, et al.; J. Biol. Chem.
284, 9059 (2009),
Abstract;
Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase: C. Schmees, et al.; Gastroenterology
132, 1820 (2007),
Abstract;
Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma: P. Ruoso & D.W. Hedley; Cancer Chemother. Pharmacol.
54, 49 (2004),
Abstract;
gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver: E. Obrador, et al.; Hepatology
35, 74 (2002),
Abstract;
S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase: N. Hogg, et al.; Biochem. J.
323 (Pt2), 477 (1997),
Abstract;
Metabolism and action of amino acid analog anti-cancer agents: G.S. Ahluwalia et al.; Pharmacol. Ther.
46, 243 (1990),
Abstract;
Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency: O.W. Griffith & A. Meister; PNAS
77, 3384 (1980),
Abstract;
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501): L. Allen, et al.; Res. Commun. Chem. Pathol. Pharmacol.
27, 175 (1980),
Abstract;
