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17-Octadecynoic acid

Fatty acid ω-hydroxylase inhibitor
BML-EI103-0010 10 mg 338.00 USD
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Potent suicide inhibitor of LTB4 ω-oxidase (IC50<5µM). Potent and selective inhibitor of fatty acid ω-hydroxylase (IC50<100 nM). Blocks biosynthesis of 20-HETE.

Product Details

Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in ethanol (25mg/ml) or DMSO (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis: J. Chan, et al.; FASEB J. 32, 3816 (2018), Application(s): Inhibition of 20-HETE biosynthesis in mice, Abstract;
Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats: A.-P. Zou, et al.; J. Pharmacol. Exp. Ther. 268, 474 (1994), Abstract;
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids: S. Shak, et al.; J. Biol. Chem. 260, 13023 (1985), Abstract; Full Text