Potent suicide inhibitor of LTB4 ω-oxidase (IC50<5µM). Potent and selective inhibitor of fatty acid ω-hydroxylase (IC50<100 nM). Blocks biosynthesis of 20-HETE.
Product Details
| Formula: | C18H32O2 |
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| MW: | 280.5 |
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| CAS: | 34450-18-5 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 67-68°C |
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| Solubility: | Soluble in ethanol (25mg/ml) or DMSO (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis: J. Chan, et al.; FASEB J.
32, 3816 (2018),
Application(s): Inhibition of 20-HETE biosynthesis in mice,
Abstract;
Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats: A.-P. Zou, et al.; J. Pharmacol. Exp. Ther.
268, 474 (1994),
Abstract;
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids: S. Shak, et al.; J. Biol. Chem.
260, 13023 (1985),
Abstract;
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