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1,2-Dioctanoyl-sn-glycerol (8:0)

PKC activator
BML-DG112-0020 20 mg 92.00 USD
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Replaces Prod. #: ALX-300-052

Potent activator of protein kinase C (PKC). Membrane permeable but non-physiologic DAG. Induces a discrete but transient translocation of protein kinase C.

Product Details

Alternative Name:DOG
Purity:≥96% (TLC)
Identity:Determined by 1H-NMR.
Appearance:Clear colorless oil or waxy solid.
Solubility:Soluble in DMSO or 100% ethanol.
Shipping:Blue Ice
Long Term Storage:-80°C
Handling:At room temperature DOG is an oil. Due to its instability, keep it cool and dry.
Technical Info/Product Notes:Avoid acidic or basic conditions.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Chitosan Mediates Germling Adhesion in Magnaporthe oryzae and Is Required for Surface Sensing and Germling Morphogenesis: I.A. Geoghegan & S.J. Gurr; PLoS Pathog. 12, e1005703 (2016), Application(s): Germinations in the presence of chemical inducers of appressorium development, Abstract; Full Text
Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently: C.M. Schophuizen, et al.; Cells 4, 234 (2015), Application(s): Cell Culture, Abstract; Full Text
1,2-Dioctanoyl-glycerol induces a discrete but transient translocation of protein kinase C as well as the inhibition of MCF-7 cell proliferation: M. Issandou & J.M. Darbon; BBRC 151, 458 (1988), Abstract;
Further studies on the specificity of diacylglycerol for protein kinase C activation: M. Go, et al.; BBRC 144, 598 (1987), Abstract;
Structural requirements of diacylglycerols for binding and activating phospholipid-dependent, Ca++-sensitive protein kinase: D.E. Kerr, et al.; BBRC 148, 776 (1987), Abstract;
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine: Y.A. Hannun, et al.; J. Biol. Chem. 260, 10039 (1985), Abstract; Full Text
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation: J.G. Ebeling, et al.; PNAS 82, 815 (1985), Abstract;
Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C: P.M. Conn, et al.; BBRC 126, 532 (1985), Abstract;
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets: E.G. Lapetina, et al.; J. Biol. Chem. 260, 1358 (1985), Abstract; Full Text
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis: R.J. Davis, et al.; J. Biol. Chem. 260, 1562 (1985), Abstract; Full Text

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