Replaces Prod. #: ALX-300-052
Potent activator of protein kinase C (PKC). Membrane permeable but non-physiologic DAG. Induces a discrete but transient translocation of protein kinase C.
Product Details
| Alternative Name: | DOG |
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| Formula: | C19H36O5 |
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| MW: | 344.5 |
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| CAS: | 60514-48-9 |
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| Purity: | ≥96% (TLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Clear colorless oil or waxy solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -80°C |
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| Handling: | At room temperature DOG is an oil. Due to its instability, keep it cool and dry. |
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| Technical Info/Product Notes: | Avoid acidic or basic conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chitosan Mediates Germling Adhesion in Magnaporthe oryzae and Is Required for Surface Sensing and Germling Morphogenesis: I.A. Geoghegan & S.J. Gurr; PLoS Pathog.
12, e1005703 (2016),
Application(s): Germinations in the presence of chemical inducers of appressorium development,
Abstract;
Full Text
Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently: C.M. Schophuizen, et al.; Cells
4, 234 (2015),
Application(s): Cell Culture,
Abstract;
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1,2-Dioctanoyl-glycerol induces a discrete but transient translocation of protein kinase C as well as the inhibition of MCF-7 cell proliferation: M. Issandou & J.M. Darbon; BBRC
151, 458 (1988),
Abstract;
Further studies on the specificity of diacylglycerol for protein kinase C activation: M. Go, et al.; BBRC
144, 598 (1987),
Abstract;
Structural requirements of diacylglycerols for binding and activating phospholipid-dependent, Ca++-sensitive protein kinase: D.E. Kerr, et al.; BBRC
148, 776 (1987),
Abstract;
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine: Y.A. Hannun, et al.; J. Biol. Chem.
260, 10039 (1985),
Abstract;
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Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation: J.G. Ebeling, et al.; PNAS
82, 815 (1985),
Abstract;
Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C: P.M. Conn, et al.; BBRC
126, 532 (1985),
Abstract;
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets: E.G. Lapetina, et al.; J. Biol. Chem.
260, 1358 (1985),
Abstract;
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sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis: R.J. Davis, et al.; J. Biol. Chem.
260, 1562 (1985),
Abstract;
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