Replaces Prod. #: ALX-450-003
A highly selective calcium ionophore which is a useful tool for increasing intracellular Ca2+ concentration. A nonfluorescent analog of A-23187 and therefore useful in the presence of fluorescent probes.
Product Details
| Formula: | C29H36BrN3O6 |
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| MW: | 602.5 |
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| CAS: | 76455-48-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in dichloromethane (clear colorless solution at 10 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain: A. Winkelmann, et al.; Cell Death Dis.
6, e1776 (2015),
Abstract;
Full Text
The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187: T. Qian, et al.; Toxicol. Appl. Pharmacol.
154, 117 (1999),
Abstract;
Ionophore bromo-A23187 reveals cellular calcium stores in single pituitary somatotropes: R.W. Holl, et al.; Mol. Cell. Endocrinol.
64, 105 (1989),
Abstract;
Calcium transport by ionophorous peptides in dog and human lymphocytes detected by quin-2 fluorescence: C.M. Deber & L.C. Hsu; BBRC
134, 731 (1986),
Abstract;
Bromo-A23187: a nonfluorescent calcium ionophore for use with fluorescent probes: C.M. Deber, et al.; Anal. Biochem.
146, 349 (1985),
Abstract;
