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Antibiotic A-23187, 4-bromo

Calcium ionophore, non-fluorescent
BML-CA101-0001 1 mg 129.00 USD
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Replaces Prod. #: ALX-450-003

A highly selective calcium ionophore which is a useful tool for increasing intracellular Ca2+ concentration. A nonfluorescent analog of A-23187 and therefore useful in the presence of fluorescent probes.

Product Details

Purity:≥98% (TLC)
Appearance:Yellow solid.
Solubility:Soluble in dichloromethane (clear colorless solution at 10 mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light and moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain: A. Winkelmann, et al.; Cell Death Dis. 6, e1776 (2015), Abstract; Full Text
The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187: T. Qian, et al.; Toxicol. Appl. Pharmacol. 154, 117 (1999), Abstract;
Ionophore bromo-A23187 reveals cellular calcium stores in single pituitary somatotropes: R.W. Holl, et al.; Mol. Cell. Endocrinol. 64, 105 (1989), Abstract;
Calcium transport by ionophorous peptides in dog and human lymphocytes detected by quin-2 fluorescence: C.M. Deber & L.C. Hsu; BBRC 134, 731 (1986), Abstract;
Bromo-A23187: a nonfluorescent calcium ionophore for use with fluorescent probes: C.M. Deber, et al.; Anal. Biochem. 146, 349 (1985), Abstract;

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