Epibatidine is an analgesic alkaloid isolated from the skin of the poison frog Epipedobates tricolor. It is the most potent nicotinic acetylcholine receptor agonist known. The natural (+) enantiomer is only 2-fold more potent than the (-) enantiomer with respect to analgesic activity in mice. Both enantiomers bind with high affinity (Ki=0.045 and 0.058 nM respectively) to rat brain membrane nicotinic receptors.
Product Details
| Formula: | C11H13ClN2 |
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| MW: | 208.7 |
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| CAS: | 140111-52-0 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (5 mg/ml) or DMSO (20 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Epibatidine, a potent analgetic and nicotinic agonist: B. Badio & J.W. Daly; Mol. Pharmacol.
45, 563 (1994),
Abstract;
Epibatidine is a nicotinic analgesic: C. Qian, et al.; Eur. J. Pharmacol.
250, R13 (1993),
Abstract;
