A substrate for the Kex2 endopeptidase from S. cerevisiae. This peptide is also a substrate for kallikrein 5 (KLK5), and a candidate substrate for the investigation of proteasome subunit function.
Product Details
| Alternative Name: | Boc-LRR-AMC |
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| Sequence: | Boc-LRR-AMC, Fluorogenic Substrate |
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| Formula: | C33H52N10O7 . 2 HCl |
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| MW: | 773.8 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects: A.T. Anastasiadi, et al.; Front. Physiol.
13, 907444 (2022),
Abstract;
Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring: V.L. Tzounakas, et al.; Redox Biol.
57, 102477 (2022),
Abstract;
20S proteasomes secreted by the malaria parasite promote its growth: E. Dekel, et al.; Nat. Commun.
12, 1172 (2021),
Abstract;
Full Text
Amniotic Fluid Proteasome and Immunoproteasome in the Setting of Intra-Amniotic Infection, Inflammation, and Preterm Birth: C.A. Ware, et al.; Reprod Sci.
28, 2562 (2021),
Abstract;
Cell cycle-dependent localization of the proteasome to chromatin: Y. Kito, et al.; Sci. Rep.
10, 5801 (2020),
Abstract;
Full Text
Mass spectrometry-based absolute quantification of 20S proteasome status for controlled ex-vivo expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells: T. Menneteau, et al.; Mol. Cell. Proteomics
18, 744 (2019),
Abstract;
Interactive effects of osmotic stress and burrowing activity on protein metabolism and muscle capacity in the soft shell clam Mya arenaria: F. Haider, et al.; Comp. Biochem. Physiol. A Mol. Integr. Physiol.
228, 81 (2018),
Abstract;
mTORC1 accelerates retinal development via the immunoproteasome: J.H. Choi, et al.; Nat. Commun.
9, 2502 (2018),
Abstract;
Full Text
A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis: S.L. Dong, et al.; Emerg. Microbes Infect.
6, e105 (2017),
Abstract;
Full Text
Proteasome properties of hemocytes differ between the whiteleg shrimp Penaeus vannamei and the brown shrimp Crangon crangon (Crustacea, Decapoda): S. Gotze, et al.; Cell Stress Chaperones
22, 879 (2017),
Abstract;
Full Text
The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System: A.C.D. Fuchs, et al.; Structure
25, 834 (2017),
Abstract;
Full Text
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun.
7, 10963 (2016),
Application(s): Western blot,
Abstract;
Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system: C. McKinnon, et al.; Acta Neuropathol.
131, 411 (2016),
Application(s): Determined trypsin-like activity,
Abstract;
Full Text
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing: Z. Wang, et al.; Cell Death Dis.
6, e1815 (2015),
Application(s): Proteasome activity assays,
Abstract;
Full Text
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts: A.D. Sklirou, et al.; Redox Biol.
5, 205 (2015),
Application(s): Fluorescent detection,
Abstract;
scyllo-Inositol promotes robust mutant Huntingtin protein degradation: A.Y. Lai, et al.; J. Biol. Chem.
289, 3666 (2014),
Abstract;
Full Text
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy: J.V. Ferreira, et al.; Autophagy
9, 1349 (2013),
Abstract;
General Literature References
Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression: I.P. Michael, et al.; J. Biol. Chem.
280, 14628 (2005),
Abstract;
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