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Pifithrin μ

HSP70 inhibitor
BML-AP503-0005 5 mg 68.00 USD
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Inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation. Pifithrin-μ has also been shown to inhibit HSP70 leading to tumor cell death associated with protein aggregation, impaired autophagy and inhibition of lysosomal function.

Product Details

Alternative Name:2-Phenylethynesulfonamide
Purity:≥98% (TLC)
Appearance:Off-white solid.
Solubility:Soluble in DMSO (>25 mg/ml) or 100% ethanol (>25 mg/ml).
Shipping:Blue Ice
Short Term Storage:-20°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Solutions can be stored at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
BML-AP503 Structure
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BML-AP503 Structure

Product Literature References

A small molecule inhibitor of inducible heat shock protein 70: J. Leu, et al.; Mol. Cell 15, 36 (2009), Abstract; Full Text
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation: E. Strom, et al.; Nat. Chem. Biol. 2, 474 (2006), Abstract;

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