Inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation. Pifithrin-μ has also been shown to inhibit HSP70 leading to tumor cell death associated with protein aggregation, impaired autophagy and inhibition of lysosomal function.
Product Details
| Alternative Name: | 2-Phenylethynesulfonamide |
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| Formula: | C8H7NO2S |
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| MW: | 181.2 |
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| CAS: | 64984-31-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (>25 mg/ml) or 100% ethanol (>25 mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A small molecule inhibitor of inducible heat shock protein 70: J. Leu, et al.; Mol. Cell
15, 36 (2009),
Abstract;
Full Text
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation: E. Strom, et al.; Nat. Chem. Biol.
2, 474 (2006),
Abstract;
